Deafness Variation Database

What It Does

• Variant classifications specific to hearing loss genes
• Expert panel curation (ClinGen Hearing Loss VCEP)
• Gene-specific ACMG criteria adaptations
• Phenotype-genotype correlations for deafness

How to Use

### Web

1. Go to https://deafnessvariationdatabase.org

2. Search: "STRC" or specific variant

3. Review expert-curated classifications

Verified Status

VERIFIED — STRC variants catalogued with hearing loss associations and classifications. Web-only access (no public API). Need to manually search for E1659A specifically.

Results (April 2026)

• STRC variants found in DVD with hearing loss associations and classifications (web-only access)
• E1659A: needs manual search on web interface (no API)
• Next: manually search DVD for E1659A, extract STRC-specific ACMG adaptations if any exist, phenotype-genotype correlations

Results (April 2026)

• STRC variants found in DVD with hearing loss associations and classifications (web-only access)
• E1659A: needs manual search on web interface (no API)
• Next: manually search DVD for E1659A, extract STRC-specific ACMG adaptations if any exist, phenotype-genotype correlations