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Hereditary Hearing Loss Homepage

VERIFIED

## Connections

hearing-loss gene-database

What It Does

  • Complete list of deafness genes and loci
  • DFNB (recessive), DFNA (dominant), DFNX (X-linked) classification
  • Gene-locus-phenotype mapping
  • Literature references per gene
  • Research group contact information

How to Use

### Web

1. Go to https://hereditaryhearingloss.org

2. Navigate: Autosomal Recessive → DFNB16 → STRC

3. View gene information, references, clinical details

Verified Status

VERIFIED — STRC listed under DFNB16. Page includes gene description, hearing phenotype, and key references.

STRC Research Usage

  • STRC Hearing Loss — reference for DFNB16 classification
  • STRC Gene — gene-locus mapping

Results (April 2026)

  • Research groups DONE: 4 key labs identified — Holt (Harvard), Shu (Fudan), Safieddine (Pasteur), Iranfar lab. Holt and Shu contacted directly.
  • Related loci: OTOF (DFNB9) is proof-of-concept for inner ear gene therapy, TMC1 (DFNB7/11) in pre-clinical
  • Next: systematic mapping of DFNB mouse models with hearing restoration data

Results (April 2026)

  • Research groups DONE: 4 key labs identified — Holt (Harvard), Shu (Fudan), Safieddine (Pasteur), Iranfar lab. Holt and Shu contacted directly.
  • Related loci: OTOF (DFNB9) is proof-of-concept for inner ear gene therapy, TMC1 (DFNB7/11) in pre-clinical
  • Next: systematic mapping of DFNB mouse models with hearing restoration data