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OrthoDB

VERIFIED

## Connections

conservation orthologs evolution

What It Does

  • Ortholog clusters across 2,000+ species
  • Conservation metrics per gene position
  • Evolutionary rate analysis
  • Functional annotations of ortholog groups
  • Phylogenetic profiles

How to Use

### Web

1. Go to https://www.orthodb.org

2. Search: "STRC" or "stereocilin"

3. View ortholog tree and conservation

### API


        curl "https://data.orthodb.org/v11/search?query=STRC&species=9606"

Verified Status

VERIFIED — STRC orthologs found: 10 ortholog groups from eukaryotes to mammals. Group 5317557at2759 = 'Stereocilin'. API: curl 'https://data.orthodb.org/v11/search?query=STRC&species=9606'. Extends our 9-species conservation analysis with broader evolutionary context.

Results (April 2026)

  • Extended conservation DONE: E1659 is 100% conserved (Glu) across 40 mammalian species from OrthoDB (pairwise alignment verified). This extends the original 9-species analysis dramatically.
  • 202 ortholog sequences retrieved from group 16757at40674
  • WARNING: raw OrthoDB sequences are UNALIGNED — must align before checking positional conservation. Naive position-based check gives wrong results.
  • Still untapped: domain-specific conservation analysis, STRCP1 pseudogene evolution timing

Results (April 2026)

  • Extended conservation DONE: E1659 is 100% conserved (Glu) across 40 mammalian species from OrthoDB (pairwise alignment verified). This extends the original 9-species analysis dramatically.
  • 202 ortholog sequences retrieved from group 16757at40674
  • WARNING: raw OrthoDB sequences are UNALIGNED — must align before checking positional conservation. Naive position-based check gives wrong results.
  • Still untapped: domain-specific conservation analysis, STRCP1 pseudogene evolution timing