Comprehensive toolkit for independent genetic variant research and hearing loss genetics analysis.
Independent Research Toolkit: This is a comprehensive collection of computational tools used in our STRC variant analysis and hearing loss genetics research. All tools are freely accessible to enable independent genetic variant research.
Total Cost: Claude Opus 4.6 API (~$50-100 for a project like this) + OpenClaw (free, open source). All scientific databases and most analysis tools are free with academic/public access.
Open source AI agent for autonomous research. Downloads files, searches databases, builds analysis pipelines.
Large language model (Anthropic). Powers the AI agent reasoning and scientific analysis.
DNA sequence → multi-modal predictions (chromatin, expression, splicing, contact maps, histone marks). API-based.
200M+ protein structure predictions with confidence scores (pLDDT). Essential for variant impact assessment.
Protein complex prediction and protein-protein interactions. Up to 5000 atoms per job.
Protein homology modeling for custom structure prediction when AlphaFold coverage is insufficient.
Modern 3D molecular visualization with WebGL. Integrated in many databases.
Professional molecular visualization software. More advanced rendering than web viewers.
All tools are designed for independent research. Most databases are free with academic access. The complete methodology is documented to enable reproduction by any family facing similar variant uncertainty.